Step 1. Having sleeping problems you need a good atmosphere because the atmosphere in your bedroom has a profound effect on how to sleep better at night and the quality of sleep you get. The overall impression should be soft and inviting rugs, soft bedding, long curtains etc. Use your favourite restful colors blue or pastels works best nothing too bright to stimulate your vision last thing at night. Make the bedroom welcoming, containing nice things you’re attached to and pleasant memories, but not too cluttered. Simple things such as closing the door makes the room more enclosed and cosy. Natural fabrics on the bed and for your nightclothes are best, as they don’t raise static electricity and the fabric breathes. Above all, have a good mattress and pillows the best you can afford.

Step 2. Eat food that can help you fall asleep. Tryptophan is an amino acid that helps the brain produce serotonin, which helps you relax. Found in such things as turkey, milk, chicken, ice cream, tuna and peanuts, the soothing effect of tryptophan can help you put your day’s worries behind you and allow you to fall into blissful slumber. On the other hand, avoid spicy and fatty foods, which can give you heartburn and keep you awake. Similarly, too much liquid before bedtime can leave you running to the bathroom all night rather than sleeping.

Step 3. When Speaking of sleep, many people find getting to sleep after a busy day very difficult. By using the technique of correct deep breathing, sleep can come much more easily and sleep will then to be much deeper. As you relax in bed, begin breathing with the diaphragm. Starting with your toes, tense them then relax them. Move to the calf muscles; continue on to the tight muscles. Then tense and relax the buttocks, abdomen and back, shoulders, neck, face and scalp. While remaining in this newly relaxed state and still breathing properly and deeply, allow your mind to take you to your special peaceful place. If the tightness in all your muscles is not completely gone or you begin to tighten up again, you can perform the tense-relax technique while in your peaceful place in your mind. Stay in that peaceful place and allow relaxation to flood over you like a wave. If sleep still does not come, you can always use the Buddhist meditation, “Breathing in I calm myself; breathing out, I find peace.” Soon you will drift away into sleep.

It happens too often.

You tossed and turned all night, but did not get a wink of sleep. What now? How will you cope today? You feel wrung out, weary to the core, and just drained of energy. Will you make it through the day today?

Surprisingly, yes!!

Here are some simple guidelines, built on experience:

1. Live for the moment. Funny thing to say, but some hours are affected differently than other hours. At one point you may feel like dropping, at others there seems to be a burst of energy and/or calm and poise. What accounts for that? Who knows!? All we do know is that such is the fact. There is little use in assuming that your day will necessarily turn out one way, when just as often it turns out entirely different - to the better!!

So go ahead and live for the moment. If you feel fine, take that as reality, and act as you would normally act with a full nights sleep. And if you feel peaked out, kick back and relax, close your eyes and daydream a bit to invigorate and recharge your batteries.

2. Plan. Think of your being short on sleep as if you were short on money. Being short on sleep means being short on energy. When you are tight on cash you budget carefully, spending on what is essential and cutting off the extras. You live within your resources and do what is necessary to make it through the difficult period. So too, when your energy resources are at a low. Think of what you really must get done - what is absolutely essential, and keep your eye on those activities. You will need to cut down on what you had planned for today, that’s for sure, so make the most out of what you can accomplish by prioritizing and choosing to do those activities that matter most.

3. Forgive yourself. You are tired and your mind is real foggy. You are not saying the smartest things today, and are barely keeping up. That’s par for the course. You are driving on low batteries today, and are making the best of it. Don’t kill yourself over your low performance. It is the best you can do today, and you can be very proud of it. There will be another time when you will shine like the superstar you really are, but today you are a good person for trying hard. Let yourself go at your diminished pace today - its all you can do. Keep your head up and forgive yourself for being mediocre; under the circumstances you are gigantic!

Addrenex Pharmaceuticals expanded its pipeline of products aimed at adrenergic regulation with the signing of an agreement to license a new drug for the treatment of narcolepsy, a chronic and debilitating sleep disorder, as well as other neurologic and psychiatric conditions.

The agreement to license ADX-N05 gives Addrenex the worldwide rights (excluding East Asia) to develop, manufacture and commercialize the compound from SK Life Science Business Division, the drug-discovery and development division of SK Holdings Co. Ltd., one of the largest multinational companies based in South Korea.

“The partnership with SK Holdings embodies our commitment to seeking global alliances that further our goal of developing drugs for adrenergic regulation,” said Steve Butts, Vice President of Commercial Operations for Addrenex Pharmaceuticals.

“We are pleased and excited to partner with an innovative, dynamic company such as SK Holdings, and we expect this to be the first of many global development partnerships for Addrenex,” he added.

The licensing deal with SK Holdings provides Addrenex with its fourth drug candidate to enter clinical trials in three years. Each of Addrenex’s drugs in development focuses on the treatment of medical conditions arising from an overactive or improperly regulated adrenergic system, a group of hormones and brain chemical messengers known as neurotransmitters. These hormones and neurotransmitters regulate diverse physiologic functions such as stress, pain, sleep and blood pressure.

Addrenex’s lead products are Clonicel(R) for the treatment of attention-deficit hyperactivity disorder (ADHD) and Sympres(R) for the treatment of hypertension. The company also plans to develop drugs to treat menopausal flushing and potentially pain, insomnia and migraines, all of which are impacted by the adrenergic system.

“ADX-N05 represents a significant advance toward expanding our product portfolio into a more diverse set of disorders for which there is a considerable unmet need for treatment,” said Moise Khayrallah, Ph.D., CEO of Addrenex Pharmaceuticals. “As an orphan disease, narcolepsy has few treatment options on the market that are safe, convenient and address all the symptoms of the disorder.”

In preclinical studies, ADX-N05 (also known as SKL-N05) has demonstrated several potential benefits over currently marketed drugs for narcolepsy, according to Khayrallah. ADX-N05 has shown the potential to treat excessive daytime sleepiness as well the associated symptom of cataplexy, an abrupt and temporary episode of weakness that can result in collapse. ADX-N05 also exhibited the potential to decrease DREM, the direct transition from wakefulness to an REM sleep state. In extensive clinical and toxicology studies, ADX-N05 was demonstrated to be safe and well tolerated.

“We are delighted to enter into a partnership with an experienced company such as Addrenex, and we are confident that Addrenex will successfully develop and commercialize ADX-N05 for the treatment of narcolepsy and other potential indications in the CNS area,” said Byong-Sung Kwak, Ph.D., Senior Executive Vice President of SK Holdings.

Addrenex plans to begin phase 2 testing of ADX-N05 as a treatment for narcolepsy later this year. The company may also investigate ADX-N05 as adjunct therapy for depression. According to Khayrallah, the compound has numerous potential applications because it is thought to engage multiple neurotransmitters, including dopamine and noradrenalin, that play a role in a variety of disorders.

Under the terms of the contract, Addrenex will pay licensing fees and royalties to SK Holdings Co. Ltd., as well as milestone payments for achieving specific clinical endpoints and sales performance goals.

About Addrenex

Addrenex specializes in the development of drugs, diagnostic tools and intervention methods aimed at normalizing adrenergic function and, thereby, helping patients regain control of symptoms related to adrenergic dysregulation. Adrenergic dysregulation is the root cause or major contributing factor for multiple medical conditions. Currently, Addrenex has three products in clinical trials and a library of over 400 compounds available for future development.

About SK Holdings (Released by SK Holdings)

SK Life Science Business, a division of SK Holdings, is actively engaged in the innovative discovery and testing of novel therapeutic compounds in the field of neuroscience to treat epilepsy, depression, anxiety, schizophrenia, neuropathic pain and neurodegenerative disorders. The company has eight new drug candidates in clinical or preclinical development, including their lead compound, Carisbamate, being developed by Johnson & Johnson Pharmaceutical Research & Development, and ADX-N05, which is ready to enter phase 2 trials. In addition to drug development, SK Life Science Business focuses on the custom manufacturing of pharmaceutical intermediates and API with unique and cost-effective technologies, including continuous reactions and low-temperature reactions.

Source: Addrenex Pharmaceuticals, Inc